While setting up our new backup server (System Centre Data Protection Manager 2012) one of the issues we came across was with it failing the data synchronizations with a error message like this one- Type: Synchronization Status: Failed Description: Changes for Volume C:\ on <servername><domainname> cannot be applied to \\?\Volume{4fac41a1-0f58-11dc-8993-806d6172696f}\ProgramData\Sophos\AutoUpdate\Cache\savxp\. (ID 112 Details: Cannot create a file when that file… Read more